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Hemoperfusion in quinidine intoxication

E J Haapanen, T J Pellinen

    Acta Medica Scandinavica
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Charcoal hemoperfusion effectively treated severe quinidine intoxication. This method significantly reduced serum quinidine levels and normalized clinical and ECG signs, suggesting it as a primary treatment option.

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    Area of Science:

    • Cardiology
    • Clinical Toxicology
    • Pharmacology

    Background:

    • Quinidine is an antiarrhythmic medication with a narrow therapeutic index.
    • Overdose can lead to severe cardiotoxicity and neurological effects.
    • Standard treatments may not rapidly eliminate quinidine in severe cases.

    Observation:

    • A patient ingested 8.1 g of quinidine, presenting with severe intoxication signs and a high serum quinidine level (8.5 mg/L).
    • The patient underwent six hours of charcoal hemoperfusion.
    • Clinical and electrocardiogram (ECG) abnormalities were monitored throughout the treatment.

    Findings:

    • Charcoal hemoperfusion reduced serum quinidine levels by an average of 36%.
    • The mean quinidine clearance achieved with hemoperfusion was 24 ml/min.

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  • All clinical and ECG signs of quinidine intoxication resolved during hemoperfusion.

    • Implications:

    • Charcoal hemoperfusion is a highly effective method for managing severe quinidine intoxication.
    • This treatment modality offers rapid reduction of quinidine levels and clinical improvement.
    • Hemoperfusion should be considered a primary therapeutic option in severe quinidine overdose cases.