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Prolonged reduction in polymorphonuclear adhesion following oral colchicine
Annals of the Rheumatic Diseases
|December 1, 1981
Summary
Colchicine significantly reduced polymorphonuclear leucocyte (PMN) adherence for up to 9 days, suggesting an effect on bone marrow precursors. This prolonged reduction in PMN adhesion may impact acute gouty arthritis pathogenesis.
Area of Science:
- Immunology
- Pharmacology
Background:
- Polymorphonuclear leucocytes (PMNs) play a crucial role in inflammatory processes.
- Colchicine is a medication used to treat inflammatory conditions like gout.
Purpose of the Study:
- To investigate the effects of a low dose of colchicine on human PMN function.
- To determine the duration of colchicine's impact on PMN adherence and motility.
Main Methods:
- Healthy subjects received 5 mg of colchicine over 24 hours.
- PMN adherence to nylon fibers was measured before and after treatment.
- PMN random motility, directed migration, and phagocytic index were assessed.
Main Results:
- Colchicine significantly reduced PMN adherence for up to 9 days.
- Random motility decreased initially but normalized by day 5.
- Directed migration and phagocytic index remained unaffected.
Conclusions:
- The prolonged reduction in PMN adherence suggests colchicine may influence PMN precursors in bone marrow.
- Altered PMN adherence could be relevant to the pathogenesis of acute gouty arthritis.