[Auto-immunity and ovarian failure (author's transl)]

The authors report the case of a 17 year-old girl presenting with primary amenorrhea. Investigations showed that it was due to auto-immune hypogonadism. Such an etiology is rarely found in ovarian insufficiencies. In the reported case, there was no other associated auto-immune disorder. Two types of anti-ovarian antibodies are known: antibodies to steroid-producing cells and antibodies to germ-cells. The first ones are found in patients presenting with auto-immune Addison's disease, and are directed against antigens common to ovary and adrenal glands and their presence does not imply ovarian dysfunction. The second ones are more specific and found chiefly in patients with sterility and amenorrhea; they are divided into 2 subgroups: antibodies against the cytoplasm of the ovacyte antibodies and antibodies against zona pellucida. In patients with primary ovarian insufficiency, the presence of such antibodies should always be investigated.