Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atherogenesis in experimental uremia

A Horsch, E Ritz, C C Heuck

    Atherosclerosis
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Symptom presentation of childbirth-related post-traumatic stress in 31 countries: the INTERSECT study.

    Journal of affective disorders·2026
    Same author

    Balancing restrictions and access to maternity care for women and birthing partners during the COVID-19 pandemic: the psychosocial impact of suboptimal care.

    BJOG : an international journal of obstetrics and gynaecology·2021
    Same author

    Tokophobia and fear of birth: a workshop consensus statement on current issues and recommendations for future research.

    Journal of reproductive and infant psychology·2020
    Same author

    The relationship between sense of coherence and post-traumatic stress: a meta-analysis.

    European journal of psychotraumatology·2019
    Same author

    What Does Big Data Mean for Wearable Sensor Systems? Contribution of the IMIA Wearable Sensors in Healthcare WG.

    Yearbook of medical informatics·2014
    Same author

    Classification of exacerbation episodes in chronic obstructive pulmonary disease patients.

    Methods of information in medicine·2014

    Short-term experimental renal insufficiency in rats did not promote atherosclerosis development. Despite increased hyperlipemia in uremic animals, aortic lipid concentration and histological abnormalities were similar to controls, suggesting renal insufficiency does not accelerate atherogenesis.

    Area of Science:

    • Nephrology
    • Cardiovascular Science
    • Experimental Pathology

    Background:

    • Atherosclerosis is a major cause of cardiovascular disease.
    • Renal insufficiency is a known risk factor for cardiovascular disease.
    • The direct impact of short-term renal insufficiency on atherogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the effect of experimental renal insufficiency on the development of atherosclerosis.
    • To determine if hyperlipemia induced by an atherogenic diet is exacerbated by renal insufficiency.
    • To assess lipid accumulation and histological changes in the aorta of uremic rats fed an atherogenic diet.

    Main Methods:

    • Subtotal nephrectomy was performed on rats to induce experimental renal insufficiency.

    Related Experiment Videos

  • Rats were pre-immunized with horseradish peroxidase and fed an atherogenic diet.
  • Control groups included sham-operated pair-fed animals.
  • Lipid profiles (triglycerides, cholesterol in VLDL and LDL fractions) and aortic wall lipid concentrations were measured.
  • Histological examination of aortic abnormalities was conducted.

    • Main Results:

    • The atherogenic diet induced hyperlipemia in both control and uremic rats.
    • Hyperlipemia was more pronounced in uremic rats compared to controls.
    • Cholesterol levels increased in VLDL and LDL fractions in both groups.
    • Despite more severe hyperlipemia, aortic wall lipid concentrations (cholesterol, phospholipids) were not significantly different between uremic and control animals.
    • No marked histological abnormalities were observed in the aorta of uremic animals compared to controls.

    Conclusions:

    • Short-term experimental renal insufficiency, even with induced hyperlipemia, does not promote the development of experimental atherosclerosis.
    • The study suggests that renal insufficiency may not be a direct promoter of atherogenesis in the short term.
    • Further research is needed to understand the long-term effects and mechanisms involved.