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Bioequivalence of Drugs: Drugs with Multiple Indications01:09

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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
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Related Experiment Video

Updated: Feb 10, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
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Uterine unification: indications and technique

C A Mercer, W N Long, J D Thompson

    Clinical Obstetrics and Gynecology
    |December 1, 1981
    PubMed
    Summary

    Uterine unification surgeries, including the Jones and Strassmann procedures, successfully improved fertility in women with müllerian anomalies. Many patients achieved pregnancy after these metroplasties, offering reproductive capability.

    Area of Science:

    • Reproductive Medicine
    • Surgical Gynecology

    Background:

    • Müllerian anomalies significantly impair reproductive capability.
    • Uterine unification metroplasties aim to correct congenital uterine malformations.

    Purpose of the Study:

    • To evaluate the reproductive outcomes of uterine unification procedures.
    • To assess the efficacy of the Jones and Strassmann procedures for treating müllerian anomalies.

    Main Methods:

    • Seventeen patients with müllerian anomalies underwent uterine unification.
    • The modified Jones procedure was used for septate uteri (15 patients).
    • The Strassmann procedure was used for bicornuate/didelphys uteri (2 patients).

    Main Results:

    • Twelve of 16 analyzed patients conceived at least once, totaling 15 pregnancies.

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  • High conception rates were observed following metroplasty.
  • Procedures demonstrated minimal surgical risks.

    • Conclusions:

    • Uterine unification procedures, specifically the Jones and Strassmann methods, are effective in enhancing fertility.
    • These surgical interventions offer a viable option for improving reproductive outcomes in patients with müllerian anomalies.