Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Limitations on dose estimation

N A Esmen

    Environmental Health Perspectives
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Estimating organ dose from environmental exposure requires careful study design. Researchers must ensure representative dose data is obtainable or that high-dose extrapolation is scientifically sound.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lung cancer mortality in UK nickel-cadmium battery workers, 1947-2000.

    Occupational and environmental medicine·2004
    Same author

    Method-induced misclassification for a respirable dust sampled using ISO/ACGIH/CEN criteria.

    The Annals of occupational hygiene·2004
    Same author

    A field comparison of the IOM inhalable aerosol sampler and a modified 37-mm cassette.

    Applied occupational and environmental hygiene·2002
    Same author

    The variability of delivered dose of aerosols with the same respirable concentration but different size distributions.

    The Annals of occupational hygiene·2002
    Same author

    A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies.

    Regulatory toxicology and pharmacology : RTP·2001
    Same author

    Use of global positioning system technology to track subject's location during environmental exposure sampling.

    Journal of exposure analysis and environmental epidemiology·2001
    Same journal

    A New Start.

    Environmental health perspectives·2026
    Same journal

    Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

    Environmental health perspectives·2026
    Same journal

    Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

    Environmental health perspectives·2026
    Same journal

    Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

    Environmental health perspectives·2026
    Same journal

    Workflow for Statistical Analysis of Environmental Mixtures.

    Environmental health perspectives·2026
    Same journal

    Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

    Environmental health perspectives·2026
    See all related articles

    Area of Science:

    • Environmental Health Sciences
    • Toxicology
    • Risk Assessment

    Background:

    • Accurate estimation of internal dose is crucial for understanding environmental agent health effects.
    • Environmental concentrations do not always directly translate to organ-specific doses.
    • Challenges exist in linking environmental measurements to biological impact.

    Purpose of the Study:

    • To theoretically examine the process of estimating target organ dose from environmental agent concentrations.
    • To analyze the implications for study design in health effects research and dose-response relationship construction.

    Main Methods:

    • Theoretical analysis of dose estimation methodologies.
    • Scrutiny of study designs for environmental health studies.
    • Evaluation of the tractability of representative dose data from environmental measurements.

    Related Experiment Videos

    Main Results:

    • The process of estimating organ dose from environmental data presents significant theoretical challenges.
    • Study designs must be critically evaluated for their ability to yield representative dose information.
    • The feasibility and desirability of extrapolating from high-dose effects require careful consideration.

    Conclusions:

    • The design of studies investigating health effects or dose-response relationships from environmental agents needs thorough scrutiny.
    • Ensuring a representative dose is tractable from environmental measurements is paramount.
    • Extrapolation from high-dose levels should be approached with caution regarding feasibility and desirability.