Dose-response analysis in animal studies: prediction of human responses

An animal bioassay has been used to evaluate a series of airborne chemicals for their sensory irritating properties to the upper respiratory tract. Teh results obtained can be used to rank their potency. An attempt has been made to predict "safe" levels of exposure for humans on the basis of this short-term assay. A good correlation was obtained between the predicted "safe" levels of exposure and current Threshold Limit Values established for industrial exposures.