Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A longitudinal electroencephalographic study in acute leukaemia

G Sideri, A Bollea, M Prencipe

    Italian Journal of Neurological Sciences
    |May 1, 1981
    PubMed
    Summary

    Electroencephalography (EEG) abnormalities are common in acute leukemia patients, indicating central nervous system involvement even without symptoms. Combination therapy, particularly radiation and methotrexate, poses the greatest risk for neurological complications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A case of motor neuron involvement in Gaucher disease.

    Molecular genetics and metabolism reports·2019
    Same author

    The different dermoscopic features of the yellow background in Langerhans and non-Langerhans cells histiocytosis.

    Clinical and experimental dermatology·2017
    Same author

    Management goals for type 1 Gaucher disease: An expert consensus document from the European working group on Gaucher disease.

    Blood cells, molecules & diseases·2017
    Same author

    The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation.

    BMC cancer·2017
    Same author

    Invasive candidiasis in pediatric intensive care in Greece: a nationwide study.

    Intensive care medicine·2013
    Same author

    [The acute renal and cerebral toxicity of lithium: a cerebro-renal syndrome? A case report].

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2013

    Area of Science:

    • Neurology
    • Oncology
    • Neurophysiology

    Background:

    • Acute leukemia frequently involves the central nervous system (CNS).
    • Clinical detection of CNS involvement can be challenging.
    • Electroencephalography (EEG) is a tool for assessing neurological function.

    Purpose of the Study:

    • To investigate the incidence and nature of EEG abnormalities in acute leukemia patients.
    • To correlate EEG findings with clinical status and treatment modalities.
    • To identify risk factors for CNS complications in leukemia.

    Main Methods:

    • A longitudinal study involving 100 patients with acute leukemia.
    • Electroencephalography (EEG) was performed on all patients.
    • Patients were categorized based on EEG results (normal vs. pathological).

    Related Experiment Videos

    Main Results:

    • A high incidence of EEG abnormalities was observed, suggesting subclinical CNS involvement.
    • Pathological EEG findings were associated with cerebro-meningeal localization.
    • Metabolic, toxic, or microcirculatory disturbances, as well as therapies, can cause EEG abnormalities.
    • The combination of radiation therapy and methotrexate showed the most significant detrimental effect on EEG.

    Conclusions:

    • EEG is a sensitive method for detecting CNS involvement in acute leukemia patients, even in the absence of clinical signs.
    • Various factors, including treatment, contribute to neurological disturbances.
    • Combined radiation and methotrexate therapy warrants careful monitoring for CNS toxicity.