[Microinjection of non-histone chromatin protein derived from mouse spleen into L cells]

Non-histone protein selectively released from mouse spleen nuclei by mild hydrolysis with micrococcal nuclease or DNase I was introduced into L cells by the microinjection method. It is shown that this protein selectively accumulates in cell nuclei. Analysis of the mitotic cells after microinjection of 125I labeled protein demonstrated its location in chromosomes of L cells.