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Amelanotic choroidal nevi

G C Brown, J A Shields, J J Augsburger

    Ophthalmology
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Amelanotic choroidal nevi are rare, appearing in 5.1% of patients. These non-pigmented lesions were observed in older, white individuals and showed no growth over time.

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    Area of Science:

    • Ophthalmology
    • Medical Imaging
    • Pathology

    Background:

    • Choroidal nevi are common benign melanocytic tumors.
    • Amelanotic variants are diagnostically challenging due to their lack of pigment.

    Purpose of the Study:

    • To characterize the clinical features and diagnostic findings of amelanotic choroidal nevi.
    • To differentiate amelanotic nevi from other amelanotic choroidal lesions.

    Main Methods:

    • Retrospective review of 373 patients with presumed choroidal nevi.
    • Analysis of lesion characteristics, patient demographics, and intravenous fluorescein angiography (IVFA) findings.
    • Mean follow-up period of 14 months.

    Main Results:

    • 19 (5.1%) patients had amelanotic choroidal nevi.

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  • Lesions occurred in older (≥48 years), white patients, posterior to the equator.
  • Mean diameter 3.2 mm, elevation ≤1 mm; IVFA showed hyperfluorescence.
  • No observed growth during follow-up.

    • Conclusions:

    • Amelanotic choroidal nevi have distinct clinical and imaging features.
    • Early and late hyperfluorescence on IVFA is characteristic.
    • Distinguishing these from amelanotic melanoma and other mimics is crucial.