Effect of unilateral nephrectomy in rabbits on pharmacokinetics of salicylate

The pharmacokinetics of salicylate was investigated in rabbits 6 months after unilateral nephrectomy. Sodium salicylate was given through the stomach gauge once in a dose of 20 mg/kg. Pharmacokinetic calculations assuming one compartment open model have revealed that in nephrectomized rabbits area under the curve (AUC) was increased by 131%, t0.5 was prolonged from 4.46 to 5.78 h, and kel was diminished by 40%. The plasma creatinine level remained unchanged and the remaining kidney was increased by 68%.