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Updated: Aug 4, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Abstract:
We will stick to the term "sclerous lymphovenous cellulitis" ("hypodermite lympho-veineuse scléreuse") to avoid any confusion with other types of cellulitis. It appears in predisposed areas; the most common zone for its development if the submalleolar region, on the internal face and behind the long saphenous vein. The asymptomatic nodule at the start spreads progressively, especially in thickness, is painful, and accompanied by oedema and cutaneous lesions. The surgical intervention uncovers a limited nodule but which remains attached at the deep posterior level of the perforants. The histology consists of a cystic fatty necrosis with secondary sclerosis; the vascular alterations are not too considerable. The aetiopathogeny is complex: the predominant factors are venous stasis in incompetent perforators and the state of the panniculus adiposus.
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