Related Experiment Video

Updated: Aug 8, 2026

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing (MTT)
12:19

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing (MTT)

Published on: May 27, 2012

Minimal transit times

L E Feinendegen

    Nuklearmedizin. Nuclear Medicine
    |October 1, 1978
    PubMed

    Insights

    Minimal cardiac transit times, a measure of blood flow velocity, are easily measured and clinically useful. This sensitive method detects subtle cardiac function changes in various heart conditions.

    Area of Science:

    • Cardiology
    • Nuclear Medicine
    • Medical Imaging

    Background:

    • Minimal cardiac transit times reflect maximal cardiac blood flow velocity.
    • These times correlate with mean velocity and ejection fraction, key indicators of heart function.

    Purpose of the Study:

    • To evaluate the sensitivity, reproducibility, and clinical utility of minimal cardiac transit times.
    • To demonstrate the method's capability in detecting subtle cardiac function alterations.

    Main Methods:

    • Utilized short-lived radionuclides and a fast gamma camera for measurement.
    • Conducted over 4,000 measurements across diverse patient groups.

    Main Results:

    • Proven sensitivity, reproducibility, and clinical usefulness in over 4,000 patient measurements.
    • Successfully applied in ischemic heart disease, myocardial insufficiency, valvular disease, and hypothyroidism.

    Conclusions:

    • Minimal cardiac transit time measurement is a highly sensitive, reproducible, and clinically valuable tool.
    • The method effectively detects minor cardiac function changes not easily identified by other means.

    More Related Videos

    Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation11:41

    Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation

    Published on: February 1, 2020

    Evaluating the Effect of Roadside Parking on a Dual-Direction Urban Street14:55

    Evaluating the Effect of Roadside Parking on a Dual-Direction Urban Street

    Published on: January 20, 2023

    Related Concept Videos

    Short-distance Transport of Resources02:12

    Short-distance Transport of Resources

    Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
    Carrier-Mediated Transport01:06

    Carrier-Mediated Transport

    Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
    Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
    Factors Influencing Drug Absorption: Anatomical Parameters01:23

    Factors Influencing Drug Absorption: Anatomical Parameters

    Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
    Noncompartmental Analysis: Statistical Moment Theory00:56

    Noncompartmental Analysis: Statistical Moment Theory

    Noncompartmental analyses leverage statistical moment theory to examine time-related changes in macroscopic events, encapsulating the collective outcomes stemming from the constituent elements in play. Statistical moment theory is a mathematical approach used to describe the time course of drug concentration in the body without assuming a specific compartmental model. SMT provides insights into drug absorption, distribution, metabolism, and elimination by treating drug concentration versus time...
    Noncompartmental Analysis: Mean Residence Time01:05

    Noncompartmental Analysis: Mean Residence Time

    According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
    After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
    Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time01:02

    Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

    When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
    One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...