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[Hepatic biopsy in acute leukemia]
Revista De Gastroenterologia De Mexico
|October 1, 1981
Summary
Liver biopsy in acute leukemia patients helps identify drug-induced hepatitis, guiding treatment modifications and improving patient outcomes. This diagnostic tool aids in managing chemotherapy
Area of Science:
- Hepatology
- Oncology
- Diagnostic Pathology
Context:
- Acute leukemia patients often exhibit altered liver function tests.
- Liver biopsies are crucial for diagnosing the cause of these abnormalities.
- Evaluating treatment side effects is essential for patient management.
Purpose:
- To determine the nature of liver lesions in acute leukemia patients.
- To assess the utility of hepatic biopsy in managing treatment-related liver complications.
- To inform therapeutic decisions based on biopsy findings.
Summary:
- Twenty-nine liver biopsies were performed on 25 acute leukemia patients with abnormal liver function tests.
- Results showed leukemic infiltration in one, nonspecific changes in 16, and drug-induced hepatitis in five patients.
- Drug-induced hepatitis necessitated chemotherapy modification, impacting survival times.
Impact:
- Hepatic biopsy is valuable for detecting adverse treatment effects in acute leukemia.
- Biopsy findings guide therapeutic decisions, potentially altering chemotherapy regimens.
- The procedure's risks and contraindications are comparable to those in non-leukemia patients.