Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclophosphamide as a potential chemosterilant for harmful snails

R Singh, R A Agarwal

    Acta Pharmacologica Et Toxicologica
    |September 1, 1981
    PubMed
    Summary

    Cyclophosphamide treatment in snails (Lymnaea acuminata) reduced DNA, RNA, and protein levels, impacting reproduction. Some recovery occurred, but protein synthesis inhibition was irreversible, suggesting potential as a snail chemosterilant.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dietary intake, plasma levels of antioxidant vitamins, and oxidative stress in relation to coronary artery disease in elderly subjects.

    The American journal of cardiology·1995
    Same author

    Role of endothelin-converting enzyme in the systemic hemodynamics and regional circulatory effects of proendothelin-1 (1-38) and diaspirin cross-linked hemoglobin in rats.

    The Journal of laboratory and clinical medicine·1995
    Same author

    Randomized double-blind comparison of the analgesic efficacy of intramuscular ketorolac and oral indomethacin in the treatment of acute gouty arthritis.

    Annals of emergency medicine·1995
    Same author

    Polymerase chain reaction-based genotyping of the constant segment of immunoglobulin kappa shows weak or no association with rheumatoid arthritis.

    Arthritis and rheumatism·1995
    Same author

    Isolated oesophageal tuberculosis: a rare cause of oesophageal stricture.

    The European journal of surgery = Acta chirurgica·1995
    Same author

    Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats.

    Indian journal of experimental biology·1995

    Area of Science:

    • * Biomolecular studies
    • * Malacology
    • * Parasitology

    Background:

    • * The snail Lymnaea acuminata is a vector for Fasciola hepatica and Fasciola gigantica.
    • * Understanding snail reproductive biology is crucial for disease control.

    Purpose of the Study:

    • * To investigate cyclophosphamide's effects on Lymnaea acuminata ovotestis.
    • * To evaluate cyclophosphamide as a potential snail chemosterilant.

    Main Methods:

    • * Administration of cyclophosphamide to snails.
    • * Biochemical analysis of ovotestis for DNA, RNA, protein, and enzyme activity.
    • * Observation of recovery post-treatment.

    Main Results:

    • * Dose-dependent reduction in DNA, RNA, protein, and alkaline phosphatase activity.
    • * Increased acid phosphatase activity and total free amino acids.
    • * Partial recovery of DNA/RNA levels, but irreversible changes in protein and enzyme activity.

    Conclusions:

    • * Cyclophosphamide affects key biomolecules in snail ovotestis.
    • * Irreversible inhibition of protein synthesis suggests chemosterilant potential.
    • * Further research needed to confirm efficacy and safety.

    Related Experiment Videos