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Gastric function in Crohn's disease

P J Whorwell, P Bennett, R Wright

    The American Journal of Gastroenterology
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Patients with Crohn's disease, especially after ileal resection, show elevated basal gastric acid secretion. Maximal and peak acid outputs were similar across Crohn's disease, ulcerative colitis, and healthy groups.

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    Area of Science:

    • Gastroenterology
    • Digestive Physiology

    Background:

    • Crohn's disease is a chronic inflammatory bowel disease.
    • Gastric acid secretion plays a role in digestive health.
    • Previous studies have yielded inconsistent findings regarding gastric acid secretion in Crohn's disease.

    Purpose of the Study:

    • To investigate gastric acid secretion in patients with Crohn's disease.
    • To compare acid secretion in Crohn's disease patients with ulcerative colitis and healthy controls.
    • To determine if ileal resection or disease location influences acid secretion.

    Main Methods:

    • Gastric acid secretion was measured before and after pentagastrin stimulation.
    • 11 patients with Crohn's disease were studied.
    • Age and sex-matched patients with ulcerative colitis and healthy controls served as comparisons.

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    Main Results:

    • Basal acid output was significantly elevated in Crohn's disease patients who had undergone surgery (P < 0.01).
    • This elevation in basal acid output was specifically linked to ileal resection, not ileal disease itself.
    • No significant differences were observed in maximal or peak acid outputs among the groups.

    Conclusions:

    • Ileal resection in Crohn's disease is associated with increased basal gastric acid secretion.
    • Gastric acid secretion patterns may differ based on surgical history in inflammatory bowel disease.
    • Further research is warranted to explore the mechanisms linking ileal resection to altered gastric acid production.