Glioma of the uterus. Report of a case with comments on histogenesis

A 15-year-old girl had a hysterectomy for intractable vaginal bleeding. Examination of the specimen revealed a polypoid tumor that filled the endometrial cavity; microscopical examination disclosed a low-grade fibrillary astrocytoma. Glial tissue in the uterus has been generally considered to arise from implantation of fetal tissue. A reliably negative coital history makes such an explanation unlikely in the present case in which the tissue appeared to be truly neoplastic and of either germ cell or mesodermal origin. The patient is free of disease 6 years later.