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Effect of styrene on hepatic mixed function oxidases, glutathione content and glutathione-s-transferase activity in
Drug and Chemical Toxicology
|January 1, 1981
Abstract:
Effect of styrene administration (250, 450 and 900 mg/kg orally for 7 consecutive days) on hepatic mixed function oxidase (MFO) enzyme activities, glutathione content and glutathione-S-transferase activity were observed. Activity of aryl hydrocarbon hydroxylase and aniline hydroxylase was significantly enhanced at higher doses of styrene (450 and 900 mg/kg). A significant lowering of glutathione content accompanied with the inhibition of glutathione-S-transferase activity was also noticed at the highest dose of styrene (900 mg/kg).