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Related Experiment Videos

Morphine and shuttlebox self-stimulation in the rat: tolerance studies

R A Levitt, D J Stilwell, T M Evers

    Pharmacology, Biochemistry, and Behavior
    |October 1, 1978
    PubMed
    Summary

    Morphine increased self-stimulation in rats by extending ON times, suggesting separate mechanisms from analgesia. Tolerance did not develop to this effect, indicating distinct neural pathways involved in morphine

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Electrical brain stimulation is used to study reward pathways.
    • Morphine is known for its analgesic properties and potential for abuse.

    Purpose of the Study:

    • To investigate the effects of morphine on self-stimulation behavior in rats.
    • To explore potential differences in mechanisms underlying morphine's effects on behavior and analgesia.

    Main Methods:

    • Rats were trained to self-administer lateral hypothalamic electrical stimulation.
    • Morphine was administered at doses of 10 mg/kg and 20 mg/kg.
    • ON and OFF times of stimulation were recorded to assess behavioral changes.

    Main Results:

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  • 10 mg/kg morphine doubled ON times without affecting OFF times; no tolerance developed.
  • 20 mg/kg morphine increased ON times 4-5 fold and also increased OFF times.
  • Tolerance partially developed to the OFF time increase but not to the ON time increase.

    • Conclusions:

    • Morphine's effect on self-stimulation ON time is dissociable from its analgesic action.
    • Separate neurological structures and receptor systems likely mediate the ON and OFF time effects of morphine.
    • The lack of tolerance to the ON time increase suggests a robust, distinct mechanism.