Linkage disequilibrium between the T/t complex and Pgk-2 in wild mice

Area of Science:

• Genetics
• Mammalian Genetics
• Population Genetics

Background:

• The T/t complex and Pgk-2 are genetic loci located near the mouse major histocompatibility complex on chromosome 17.
• Understanding the linkage disequilibrium between these loci is crucial for studying mouse chromosome 17 organization and evolution.

Purpose of the Study:

• To investigate the linkage disequilibrium between the T/t complex and the Pgk-2 locus in a wild mouse population.
• To characterize the allelic phase of T/t, Pgk-2, and Ce-2 in wild male mice.

Main Methods:

• Progeny testing of 78 wild male mice.
• Extraction and characterization of recessive t haplotypes.
• Determination of allelic phase for T/t, Pgk-2, and Ce-2.

Main Results:

• Linkage disequilibrium was detected between the T/t complex and Pgk-2 in the studied wild mouse population.
• Fifteen recessive t haplotypes were identified, with 12 assigned to the tw5 complementation group.
• The Pgk-2c allele was found to be consistently associated with a t haplotype, though not exclusively.

Conclusions:

• The study confirms linkage disequilibrium between the T/t complex and Pgk-2 in wild mice.
• A strong association exists between the Pgk-2c allele and t haplotypes, suggesting a conserved genetic linkage.
• These findings contribute to the understanding of genetic architecture on mouse chromosome 17.