Study of cell-mediated immunity in B77 tumor bearing rats by 51chromium release assay

Cell immunity was followed in Lewis rats with transplanted syngeneic B77 tumors, by means of the cytotoxic 51chromium release test. Lymphocytes from peripheral blood, or from regional lymph nodes of tumor bearing animals, cocultured for 24 h with target B77 cells had an enhanced cytotoxic effect on target cells in comparison with lymphocytes of control donors. This effect of the lymphocytes still increased during 48 h of coculture.