Related Experiment Videos
[Extrapyramidal disorders in ischemic strokes]
Insights
This study investigated extrapyramidal disturbances following ischemic cerebral stroke in 52 patients. Findings link specific syndromes to carotid or vertebrobasilar artery involvement, aiding understanding of stroke complications.
Area of Science:
- Neurology
- Clinical Neuroscience
- Vascular Neurology
Background:
- Hypertensive disease and atherosclerosis are major risk factors for ischemic cerebral stroke.
- Ischemic stroke can lead to complex neurological deficits, including extrapyramidal disturbances.
- Understanding the relationship between vascular territories and specific syndromes is crucial for patient management.
Observation:
- Fifty-two patients with ischemic cerebral stroke, hypertensive disease, and atherosclerosis were evaluated.
- Electromyographic and pathomorphological examinations were conducted in a subset of patients.
- Clinical presentations of extrapyramidal disturbances were correlated with affected cerebral vascular basins.
Findings:
- Ischemic strokes in the carotid artery basin were associated with contralateral extrapyramidal-pyramid syndrome, homolateral extrapyramidal syndrome, or hyperkinetic syndrome.
- Ischemic strokes in the vertebrobasilar basin were linked to extrapyramidal-pyramid-pseudobulbar syndrome or akinetic rigidity syndrome.
- Comparison with pathoanatomical findings refined understanding of the pathogenetic mechanisms of these disturbances.
Implications:
- The study clarifies the clinical manifestations of extrapyramidal disturbances in ischemic stroke based on vascular territory.
- Findings contribute to a deeper understanding of the pathophysiology of post-stroke movement disorders.
- This knowledge can potentially improve diagnostic accuracy and therapeutic strategies for stroke patients with extrapyramidal symptoms.
Abstract:
The clinical picture of the extrapyramid disturbances was examined in 52 patients with hypertensive disease and atherosclerosis who had suffered an ischemic cerebral stroke. In 40 cases electromyographic, and in 26 cases pathomorphological examinations were performed. The extrapyramid disturbances are demonstrated with reference to the affection of one or another vascular basin. In ischemic strokes associated with circulatory disorders in the carotid artery basin the following variants of the extrapyramid disturbances were revealed : a) contralateral extrapyramid-pyramid syndrome; b) homolateral extrapyramid syndrome; c) hyperkinetic syndrome. In ischemic strokes due to circulatory disorders in the vertebrobasilar basin the disturbances revealed were: extrapyramid-pyramid-pseudobulbar syndrome (a variant of Filimonov's syndrome) and akinetic rigidity syndrome. The results of the above clinico-physiological examinations were compared with pathoanatomical findings. This comparison has made it possible to expand to a certain extent and concepts about the pathogenetic mechanisms underlying the complicate clinical picture of the extrapyramid disturbances developed in ischemic cerebral stroke.