Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous morphines and pain

J Jacob

    Agents and Actions
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Endogenous morphines, like enkephalins and endorphins, regulate pain perception and response. These natural opioids modulate nociception, influencing behavior and preventing exhaustion from unavoidable pain stimuli.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Search for decays of stopped long-lived particles produced in proton-proton collisions at [Formula: see text].

    The European physical journal. C, Particles and fields·2015
    Same author

    Measurement of the inclusive 3-jet production differential cross section in proton-proton collisions at 7 TeV and determination of the strong coupling constant in the TeV range.

    The European physical journal. C, Particles and fields·2015
    Same author

    Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis.

    Cell death & disease·2015
    Same author

    Measurement of electroweak production of two jets in association with a Z boson in proton-proton collisions at [Formula: see text].

    The European physical journal. C, Particles and fields·2015
    Same author

    Observation of the diphoton decay of the Higgs boson and measurement of its properties.

    The European physical journal. C, Particles and fields·2015
    Same author

    Measurement of differential cross sections for the production of a pair of isolated photons in pp collisions at [Formula: see text].

    The European physical journal. C, Particles and fields·2015
    Same journal

    Classification and biological distribution of histamine receptor sub-types. 1975.

    Agents and actions·1994
    Same journal

    Metiamide--an orally active histamine H2-receptor antagonist. 1973.

    Agents and actions·1994
    Same journal

    A brief survey of the history of inflammation. 1978.

    Agents and actions·1994
    Same journal

    The discovery of librium. 1972.

    Agents and actions·1994
    Same journal

    Notes and documents concerning the discovery of LSD. 1970.

    Agents and actions·1994
    Same journal

    Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41,468), a selective 5-HT2-receptor antagonist. 1982.

    Agents and actions·1994
    See all related articles

    Area of Science:

    • Neuroscience
    • Pain Research
    • Pharmacology

    Background:

    • Endogenous morphines (enkephalins, endorphins) are implicated in pain regulation.
    • Evidence includes their analgesic effects and distribution in the central nervous system.

    Purpose of the Study:

    • To review experimental evidence demonstrating the role of endogenous morphines in pain.
    • To highlight specific factors influencing pain modulation, including hypothalamic and pituitary roles.

    Main Methods:

    • Review of experimental evidence on endogenous morphines and pain.
    • Analysis of analgesic activities, CNS distribution, and effects of modifiers (antagonists).
    • Examination of brain level modifications in pain/analgesic states.

    Main Results:

    Related Experiment Videos

    • Endogenous morphines exhibit analgesic activities and are distributed within the CNS.
    • Antagonists and modifiers significantly impact nociceptive reactions and analgesia.
    • Brain levels of endogenous morphines show rare modifications during pain or analgesic states.

    Conclusions:

    • Endogenous morphines filter nociceptive input and control pain reactions.
    • They enable adaptive behaviors for avoidable stimuli and prevent exhaustion from unavoidable stimuli.
    • Factors like hypothalamic/pituitary function, genetics, and biogenic amines modulate these effects.