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White liver disease in lambs

R B Richards, M R Harrison

    Australian Veterinary Journal
    |December 1, 1981
    PubMed
    Summary

    An outbreak of white liver disease in lambs in Western Australia caused liver damage and high mortality. Vitamin B12 therapy proved effective in treating affected lambs.

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    Area of Science:

    • Veterinary Pathology
    • Animal Science
    • Toxicology

    Background:

    • An outbreak of a novel disease affecting lambs in Western Australia was investigated.
    • The condition presented with severe clinical signs and high mortality rates in young sheep.

    Purpose of the Study:

    • To describe the clinical and pathological characteristics of the disease outbreak.
    • To identify potential causes and effective treatments for the observed lamb mortality.

    Main Methods:

    • Clinical observations and post-mortem examinations of affected lambs were conducted.
    • Epidemiological data from the affected properties were collected and analyzed.
    • Response to therapeutic interventions, specifically vitamin B12, was evaluated.

    Main Results:

    • The disease primarily affected 2- to 3-month-old lambs, characterized by liver damage.
    • Clinical signs included severe ill-thrift, depression, ocular discharge, photosensitization, and transient neurological signs.
    • A significant positive response to vitamin B12 supplementation was observed, indicating a potential deficiency or metabolic disruption.

    Conclusions:

    • The described syndrome in Western Australian lambs is associated with liver pathology and responds to vitamin B12.
    • Further research is warranted to elucidate the specific etiology and pathogenesis of this white liver disease.
    • Vitamin B12 supplementation should be considered in the management of similar outbreaks in young lambs.

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