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Gel layer limited haemofiltration rates can be increased by vortex mixing
Clinical and Experimental Dialysis and Apheresis
|January 1, 1981
Summary
This study enhances ultrafiltration flow rates (UFR) in haemofiltration for chronic renal failure treatment. By inducing vortex mixing through pulsed blood flow, UFR was increased eightfold compared to steady flow methods.
Area of Science:
- Nephrology
- Biomedical Engineering
- Fluid Dynamics
Background:
- Haemofiltration is an established alternative to haemodialysis for chronic renal failure since 1976.
- Ultrafiltration flow rates (UFR) are typically slow and reach a maximum independent of transmembrane pressure (delta Pm) with highly permeable membranes.
Purpose of the Study:
- To investigate methods for increasing ultrafiltration flow rates (UFR) beyond the observed maximum.
- To evaluate the effect of induced vortex mixing on UFR in haemofiltration devices.
Main Methods:
- Confirmation of maximum UFR under steady flow conditions using a polyacrylonitrile membrane (Rhône Poulenc AN 69).
- Induction of vortex mixing by pulsing blood flow over furrowed channels within the ultrafilter.
Main Results:
- Steady flow UFR confirmed to reach a maximum independent of delta Pm.
- Pulsed blood flow with vortex mixing increased UFR by a factor of eight compared to steady flow.
Conclusions:
- Vortex mixing via pulsed blood flow significantly enhances ultrafiltration efficiency.
- This technique offers a potential method to improve haemofiltration performance for chronic renal failure patients.