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Hydrogel keratophakia in non-human primates

P S Binder, J K Deg, E Y Zavala

Current Eye Research

|January 1, 1981

Summary

Hydrogel lenses were used as donor corneas in keratophakia surgery on non-human primates. This innovative technique successfully steepened corneas and offers a potential alternative to human donor corneas for aphakia correction.

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Area of Science:

Ophthalmology
Biomaterials Science

Background:

Keratophakia is a refractive surgical procedure used to correct aphakia.
Human donor corneas are currently used as donor lenticules in keratophakia.
Challenges exist with donor cornea availability and transplantation.

Purpose of the Study:

To evaluate the feasibility of using hydrogel lenses as donor corneas in keratophakia.
To assess the surgical outcomes and tolerability of hydrogel lenticules in non-human primates.

Main Methods:

Sixteen keratophakia procedures were performed on nine non-human primates.
Various hydrogel lenses with water content ranging from 38% to 79% were used as donor lenticules.
Standard keratophakia techniques, including microkeratome resection and lamellar pocket dissection, were employed.
Lenses were cryolathed, sometimes with modified computer programs, before insertion.

Main Results:

The surgical technique successfully steepened recipient corneas up to 44.8 diopters.
The hydrogel lenticules were well tolerated by the non-human primates for over three months.
The procedure demonstrated the potential for hydrogel lenses to serve as viable donor corneas.

Conclusions:

Hydrogel lenses can be effectively utilized as donor corneas in keratophakia procedures.
This approach may overcome limitations associated with human donor cornea transplantation.
Further research could establish hydrogel lenses as a safe and effective alternative for refractive correction in aphakia.

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