Human pharmacokinetics of indoprofen

The pharmacokinetics of indoprofen were investigated in several studies in healthy volunteers and in rheumatoid arthritis patients. In healthy subjects the drug is rapidly eliminated with a biological half-life of 2.3 h. The drug and its metabolites are almost completely excreted in urine within 24 h from administration. The absorption of indoprofen administered orally to fasting subjects as 100 mg capsules and 200 mg tablets is rapid and complete. The bioavailability of indoprofen tablets is not adversely affected by the presence of food in the gastrointestinal tract. Following administration of 600 mg of indoprofen per day for 7 days, no changes are observed in the drug plasma level profile. There are no substantial differences between healthy subjects and rheumatoid arthritis patients as regards the pharmacokinetics properties of oral indoprofen.