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Interaction of glipizide and indoprofen
European Journal of Rheumatology and Inflammation
|January 1, 1981
Summary
Indoprofen may lower glipizide plasma concentrations in healthy volunteers. However, this interaction did not significantly affect the blood glucose-lowering response to glipizide.
Area of Science:
- Pharmacology
- Clinical Pharmacology
- Drug Interactions
Background:
- Indoprofen is a non-steroidal anti-inflammatory drug (NSAID).
- Glipizide is an oral hypoglycemic agent used to treat type 2 diabetes.
- Potential drug interactions between NSAIDs and sulfonylureas warrant investigation.
Purpose of the Study:
- To investigate the pharmacokinetic and pharmacodynamic interactions between indoprofen and glipizide.
- To assess the effect of indoprofen on glipizide plasma concentrations.
- To evaluate the impact of indoprofen on the blood glucose-lowering efficacy of glipizide.
Main Methods:
- A study was conducted in 6 healthy volunteers.
- Volunteers received indoprofen (200 mg three times daily) for 7 days.
- A single dose of glipizide (5 mg) was administered before and during indoprofen treatment.
- Blood and urine samples were collected for analysis of indoprofen and glipizide concentrations using High-Performance Liquid Chromatography (HPLC).
- Blood glucose concentrations were measured enzymatically.
Main Results:
- Indoprofen administration appeared to decrease glipizide plasma concentrations.
- No significant alteration in the blood glucose response to glipizide was observed despite changes in glipizide levels.
- Urinary concentrations of indoprofen were also determined.
Conclusions:
- Indoprofen may have a modest impact on glipizide pharmacokinetics.
- The observed pharmacokinetic interaction does not seem to translate into a clinically significant change in glipizide's glucose-lowering effect.
- Further studies may be needed to confirm these findings in diabetic patients.