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Updated: Aug 18, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
N-Substituted aryl compounds in carcinogenesis and mutagenesis
Abstract:
A brief history of the development of synthetic dyes derived from aromatic amines is given and the later consequences on workers' health. Metabolic studies and carcinogenicity tests of aromatic amines showed that the differences in susceptibility of various species to the amines cannot always be explained on the basis of metabolic handling of amines. Tests for mutagenicity of aromatic amines in histidine-dependent strains of the bacterium. Salmonella typhimurium, are often useful as indicators of possible carcinogens. However, the mutagenicity tests gave a false positive result when compared with those from carcinogenicity studies of the same compounds.
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