Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological changes in tropical sprue

I N Ross, V I Mathan

    The Quarterly Journal of Medicine
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Tropical sprue involves increased intraepithelial lymphocytes in the jejunum. This small intestinal enterocyte abnormality is a consequence of mucosal damage, not a primary immune issue.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of a novel large bandwidth front-end system for high peak power OPCPA systems.

    Optics express·2011
    Same author

    Binary phase zone-plate arrays for laser-beam spatial-intensity distribution conversion.

    Applied optics·2010
    Same author

    High-brightness femtosecond laser using titanium-sapphire technology and amplification in dyes.

    Applied optics·2010
    Same author

    Single shot measurement of pulse duration for a picosecond pulse at 249 nm.

    Applied optics·2010
    Same author

    High-resolution holographic image projection at visible and ultraviolet wavelengths.

    Applied optics·2010
    Same author

    Colloidal silica coatings for KrF and Nd:glass laser applications.

    Applied optics·2010
    Same journal

    Megaloblastic anaemia of pregnancy and the puerperium; a review of forty-five cases with special reference to their response to treatment.

    The Quarterly journal of medicine·2014
    Same journal

    Carcinoma of the bronchus; a clinical and pathological survey of 866 cases.

    The Quarterly journal of medicine·2014
    Same journal

    Heart failure in acute nephritis.

    The Quarterly journal of medicine·2014
    Same journal

    Uraemia complicating low salt treatment of heart failure.

    The Quarterly journal of medicine·2014
    Same journal

    The effect of tobacco on lung-volume.

    The Quarterly journal of medicine·2014
    Same journal

    Chronic monocytic leukaemia.

    The Quarterly journal of medicine·2014
    See all related articles

    Area of Science:

    • Gastroenterology
    • Immunology
    • Pathology

    Background:

    • Tropical sprue is a malabsorptive condition prevalent in Southern India.
    • Its underlying pathophysiology, particularly the role of immunological factors, requires further elucidation.

    Purpose of the Study:

    • To investigate the immunological profile of patients with tropical sprue.
    • To compare these findings with gastrointestinal disease controls and healthy subjects.
    • To determine if immunological processes are primary drivers or secondary consequences of the disease.

    Main Methods:

    • Immunological markers were measured in 85 Southern Indian tropical sprue patients.
    • Comparison groups included 150 gastrointestinal disease patients (non-malabsorptive) and 57 healthy controls.

    Related Experiment Videos

  • Histopathological analysis of jejunal biopsies focused on intraepithelial lymphocytes.

    • Main Results:

    • A significant increase in jejunal intraepithelial lymphocytes correlated with mucosal abnormality severity in tropical sprue.
    • Elevated serum IgG, IgE, C4, orosomucoid, and presence of gastric parietal cell antibodies were noted.
    • Lymphopenia with low T cell counts was observed, differing from healthy controls but not non-malabsorptive GI controls.
    • Functional antibody production remained intact.

    Conclusions:

    • The small intestinal enterocyte abnormality in tropical sprue appears to be a sequela of mucosal damage.
    • Compromised mucosal barrier integrity, rather than a primary immunological process, likely underlies the observed immunological alterations.