Stomach absorption of intubated insecticides in fasted mice

Eight 14C-labeled insecticides representing diverse chemical classes were intubated into fasted mice whose stomachs were ligated at the pylorus. Absorption through the stomach was measured at 3 time intervals over a 60-min period and compared to similar absorption studies in the entire gastrointestinal tract. The percent of stomach absorption (as contrasted to total gastrointestinal absorption) varied from 29% (carbaryl) to 10% (nicotine). Distribution following stomach absorption was found to be similar to that in the gastrointestinal tract.