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Related Experiment Videos

[Alkaline phosphatase isoenzymes and hyperthyroidism]

R Hampel, S Weber, H J Rose

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |December 1, 1981
    PubMed
    Summary

    Alkaline phosphatase isoenzymes, specifically the osseous isoenzyme, are elevated in hyperthyroidism, reflecting bone metabolism disturbances. This osseous isoenzyme serves as a sensitive indicator of thyroid gland function.

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    Area of Science:

    • Biochemistry
    • Endocrinology
    • Clinical Chemistry

    Context:

    • Hyperthyroidism is associated with altered bone metabolism.
    • Assessing thyroid function often involves biochemical markers.

    Purpose:

    • To investigate serum total alkaline phosphatase and its isoenzyme patterns in hyperthyroid patients.
    • To compare these patterns with healthy controls and euthyroid states.
    • To evaluate the diagnostic utility of alkaline phosphatase isoenzymes in hyperthyroidism.

    Summary:

    • Serum total alkaline phosphatase and osseous isoenzyme levels are elevated in untreated hyperthyroidism.
    • The L/K quotient, reflecting isoenzyme patterns, is significantly lower in hyperthyroid individuals.
    • Osseous alkaline phosphatase elevation can occur even when total alkaline phosphatase remains within normal limits, indicating early bone changes.

    Impact:

    • The osseous alkaline phosphatase isoenzyme is a sensitive and specific marker for peripheral thyroid function.
    • Monitoring osseous isoenzyme levels can aid in assessing hyperthyroidism and its treatment response.
    • Understanding these biochemical changes aids in managing hyperthyroidism-related bone complications.

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