[Antibiotherapy of purulent meningitis in Africa in 1981]

The place of the different anti-bacterial drugs in the treatment of purulent meningitis must be reconsidered in view of the bacteriological pharmacological and socio-economical data. Sulphonamids have no more interest because of the multiplication of resistant strains in most of the bacterial species. Penicillin G, with a narrow spectrum, keeps good indications (Meningococci and Pneumococci) but its use lacks convenience. With its very broad spectrum of activity, its long half life and its low cost, Chloramphenicol is actually the reference drug well adapted to the particular conditions of Africa. Ampicillins, often too expensive, show a more and limited activity against gram negative pathogens and should be supplied by the Cephalosporins "of the last generation" if not so costly.