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Spontaneous mesangioproliferative glomerulonephritis in pigtailed macaques (Macaca nemestrina)
Abstract:
Mesangioproliferative glomerulonephritis was found in 28 of 113 pigtailed macaques (Macaca nemestrina) that died in 1977. In five it was considered severe enough to cause significant renal dysfunction; in two of these it was the cause of death. The basic lesion was a proliferation of mesangial cells and deposition of mesangial matrix in the mesangial stalk, resulting in various degrees of stalk expansion and increased lobulation of the glomerular tuft. Preliminary immunofluorescence and ultrastructural studies suggests the pathogenesis of the lesion may involve deposition of antigen-IgM immune complexes in the mesangial region.
Insights
Mesangioproliferative glomerulonephritis affected 28 macaques, with severe cases causing renal dysfunction and death. Pathogenesis may involve immune complex deposition in the mesangial region.
Area of Science:
- Veterinary Pathology
- Nephrology
- Immunology
Background:
- Mesangioproliferative glomerulonephritis is a kidney disease.
- Pigtailed macaques (Macaca nemestrina) can develop renal pathologies.
Purpose of the Study:
- To investigate the incidence and characteristics of mesangioproliferative glomerulonephritis in pigtailed macaques.
- To explore the potential pathogenesis of this renal lesion.
Main Methods:
- Necropsy and histopathological examination of 113 deceased pigtailed macaques.
- Preliminary immunofluorescence and ultrastructural studies.
Main Results:
- Mesangioproliferative glomerulonephritis was diagnosed in 28 macaques.
- Five cases exhibited severe renal dysfunction, with two deaths attributed to the condition.
- The lesion involved mesangial cell proliferation and matrix deposition, expanding the mesangial stalk.
Conclusions:
- Mesangioproliferative glomerulonephritis occurs in pigtailed macaques and can lead to severe renal dysfunction.
- Immune complex deposition, potentially involving antigen-IgM, is suggested as a contributing factor to the pathogenesis.