Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum complement factors in human acute pancreatitis

P G Lankisch, H Koop, U Kaboth

    Hepato-Gastroenterology
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Choosing wisely recommendations in gastroenterology].

    Der Internist·2017
    Same author

    [Erratum to: "Choosing wisely" in infectious diseases : Overuse of antibiotics - too few vaccinations].

    Der Internist·2016
    Same author

    ["Choosing wisely" in infectious diseases : Overuse of antibiotics - too few vaccinations].

    Der Internist·2016
    Same author

    [S2k guideline: gastroesophageal reflux disease guided by the German Society of Gastroenterology: AWMF register no. 021-013].

    Zeitschrift fur Gastroenterologie·2014
    Same author

    [Procain Infusion in Pain Treatment of Acute Pancreatitis: yes or no, that is the Question].

    Zeitschrift fur Gastroenterologie·2012
    Same author

    Concomitant use of thrombocyte aggregation inhibitors and proton pump inhibitors (PPIs).

    Zeitschrift fur Gastroenterologie·2011

    Lowered serum complement factors (C3, C4) indicate a poor prognosis in acute pancreatitis patients. Monitoring complement levels may aid in predicting disease severity and patient outcomes.

    Area of Science:

    • Immunology
    • Gastroenterology
    • Clinical Medicine

    Background:

    • Serum complement levels, including C3, C4, and total hemolytic activity, are crucial indicators in inflammatory conditions.
    • Acute pancreatitis is a severe gastrointestinal disease with significant morbidity and mortality.
    • The role of complement system activation in the pathogenesis and prognosis of acute pancreatitis requires further elucidation.

    Purpose of the Study:

    • To investigate the prognostic significance of serum complement factors in patients with acute pancreatitis.
    • To explore potential mechanisms behind complement factor alterations during acute pancreatitis.

    Main Methods:

    • Serum samples from 35 acute pancreatitis patients were analyzed for C3, C4, and total hemolytic complement activity.

    Related Experiment Videos

  • Patient outcomes, including survival and disease course, were correlated with complement levels.
  • Immunohistochemical analysis for C3 deposits was performed in select cases.

    • Main Results:

    • In 24 out of 35 patients (primarily survivors), complement levels were normal or elevated.
    • Three patients with initially low complement levels showed normalization with clinical recovery.
    • Eight patients with generally lowered or declining complement factors all succumbed to hemorrhagic pancreatitis, indicating a poor prognostic sign.

    Conclusions:

    • Lowered serum complement factors (C3, C4) are associated with an unfavorable prognosis in acute pancreatitis.
    • Potential reasons for complement decline include protein loss, coagulation disturbances, or intrapancreatic complement activation.
    • Immunohistochemical findings support the intrapancreatic activation of complement in severe cases.