[Transformation of connective tissue cells by pathological altered synovial fluid as demonstrated by experimental...

Joint cavities and tendon sheaths are fissurations in the mesenchyme. The coating synovial lining cell layer is caused through the environment of the synovial fluid. The pathologically altered synovial fluid initiates the transformation and proliferation of the marginal connective tissue cells. Evidence for this thesis are the synovial transformatory processes of the cutaneous connective tissue in the area of a synovial fistula and the formation of synovial like structures in the subcutaneous fatty tissues of the rat following the application of synovial fluid from patients with rheumatoid arthritis.