[Temporal bone histopathology in a case of trisomy 22-syndrome (author's transl)]

This premature female infant died soon after birth. She had numerous gross anomalies and was found on cytogenic studies to have Trisomy 22. Polytomographic and histologic studies of the left ear revealed multiple anomalies including complete aural atresia, non-pneumatization of the middle ear with a vertical shelf of bone in the mid portion of the middle ear, absence of the stapes and oval window and bony closure of the round window niche. The cochlea is flat in shape and shows one and a half turns with incomplete formation of the modiolus. The intersaccular septum is rudimentary but the spiral ganglion is clearly seen in Rosenthal's canal through the one and a half turns. The organ of Corti is well developed and contains hair cells. The stria vascularis is present. The utricular and saccular maculae as well as all cristae are well developed and contain hair cells. The saccular wall is collapsed onto an atrophic appearing otolithic membrane. The utricle is dilated, the lateral semicircular canal appears short and the bony canal is wide. The flattened and shortened cochlea with deformities of the cochlear duct, and the large vestibule resembles Mondinis dysplasia.