The effect of chronic neonatal guanethidine treatment on body composition in pigs

The effect of neonatal guanethidine administration (30 mg/kg/day) during the first 32 days of life on body composition at 20 weeks of age, was assessed in two breeds of pig which were known to differ in their sympathetic responsiveness. Guanethidine administration increased the proportion of fat and decreased the proportion and absolute weight of lean in the Pietrain breed; and it had no effect in Gloucester Old Spots. Thus it can be inferred that endogenous noradrenaline is responsible for promoting leanness in a pig breed with known sympathetic overactivity.