Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidation and metabolic interconversion in malignant cachexia

C Waterhouse

    Cancer Treatment Reports
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    How patent law reform can improve affordability and accessibility of medicines in South Africa: Four medicine case studies.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2019
    Same author

    Surveillance of infection associated with external ventricular drains: proposed methodology and results from a pilot study.

    The Journal of hospital infection·2016
    Same author

    Successful pregnancy after liver transplantation in progressive familial intrahepatic cholestasis, type 1.

    Pediatric transplantation·2010
    Same author

    Kidney function studies in adrenal insufficiency.

    The Journal of clinical investigation·2010
    Same author

    Building Canada's health research capacity within the framework of the Canadian Institutes of Health Research.

    Paediatrics & child health·2010
    Same author

    The Glasgow Coma Scale and other neurological observations.

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2005
    Same journal

    Rhabdomyolysis associated with high-dose cytarabine.

    Cancer treatment reports·1987
    Same journal

    Acute laryngeal edema after single-dose irradiation and doxorubicin.

    Cancer treatment reports·1987
    Same journal

    Timing may be a critical factor in drug therapy.

    Cancer treatment reports·1987
    Same journal

    Prednimustine in advanced malignant melanoma: a phase II study.

    Cancer treatment reports·1987
    Same journal

    Phase II evaluation of diaziquone in pancreatic carcinoma: a Southwest Oncology Group Study.

    Cancer treatment reports·1987
    Same journal

    Teniposide in metastatic renal and bladder cancer: a Southwest Oncology Group Study.

    Cancer treatment reports·1987
    See all related articles

    Cancer patients exhibit altered metabolism, with increased fatty acid oxidation and abnormal branched-chain amino acid regulation. These metabolic changes suggest impaired insulin and glucose signaling in malignant disease.

    Area of Science:

    • Metabolic alterations in cancer
    • Nutrient metabolism in malignant disease
    • Hormonal regulation of metabolism

    Background:

    • Patients with progressive malignant disease may experience changes in metabolic expenditure.
    • Previous studies indicate complex metabolic shifts in cancer patients, but findings are inconsistent.
    • Understanding these metabolic changes is crucial for managing cancer cachexia and improving patient outcomes.

    Purpose of the Study:

    • To investigate specific metabolic changes in patients with malignant disease.
    • To analyze substrate utilization, particularly fatty acids and amino acids.
    • To examine the regulation of glycolysis, gluconeogenesis, and branched-chain amino acid metabolism.

    Main Methods:

    • Comparative analysis of substrate oxidation (fatty acids, glucose, amino acids) in cancer patients versus normal subjects.

    Related Experiment Videos

  • Assessment of metabolic responses to exogenous glucose administration.
  • Evaluation of branched-chain amino acid (leucine) metabolism under conditions of semistarvation and glucose administration.

    • Main Results:

    • Fatty acids are the predominant energy substrate, with increased proportions utilized in oxidative metabolism in cancer patients, especially with available glucose.
    • Increased glycolysis and gluconeogenesis are observed post-fasting but are suppressed by glucose; however, leucine metabolism is not under normal control.
    • Branched-chain amino acid levels are not diminished by semistarvation and are not suppressed by glucose, with increased leucine turnover and oxidation.

    Conclusions:

    • Cancer patients display altered substrate metabolism, including increased reliance on fatty acids and dysregulated amino acid metabolism.
    • Peripheral insulin and glucose effects may not be normally mediated in patients with malignant disease.
    • Amino acid and protein metabolism may be independent of normal regulatory factors in the context of cancer.