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[The effects of digoxin administration on normal and pathological sinus node function. An electrophysiological study
Giornale Italiano Di Cardiologia
|January 1, 1981
Summary
Digoxin negatively impacts sinus node function, particularly in patients with sick sinus syndrome. This study suggests digoxin may worsen electrophysiological parameters in these individuals.
Area of Science:
- Electrophysiology
- Cardiology
Context:
- Sick sinus syndrome (SSS) is a common cause of bradycardia.
- Digoxin is a medication used to treat heart conditions, but its effects on sinus node function require further investigation.
Purpose:
- To evaluate the effects of acute digoxin administration on sinus node function in normal subjects, patients with asymptomatic sinus bradycardia, and symptomatic sick sinus syndrome.
- To assess the role of parasympathetic action in mediating digoxin's effects.
Summary:
- Acute digoxin administration significantly lengthened sinus node cycle length in all groups.
- Sinus node recovery time and corrected sinus node recovery time worsened, especially in patients with symptomatic sick sinus syndrome.
- Atropine administration following digoxin suggested complex interactions affecting sinus node parameters.
Impact:
- This study challenges existing literature by suggesting digoxin can impair sinus node electrophysiological parameters, particularly in symptomatic sick sinus syndrome patients.
- Findings highlight the need for careful consideration of digoxin use in patients with sinus node dysfunction.