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[The lipoproteic state in patients with coronary heart disease (author's transl)]
Insights
Lipid profiles reveal differences in coronary heart disease (CHD) patients compared to healthy individuals. Men with CHD show reduced HDL and increased risk factors, while women exhibit lower HDL with higher cholesterol and triglycerides.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Biochemistry
Context:
- Coronary heart disease (CHD) is a significant global health concern.
- Lipoprotein profiles are crucial indicators of cardiovascular risk.
- Understanding age- and sex-related lipid changes is vital for risk assessment.
Purpose:
- To analyze and compare the lipoproteic state in patients with coronary heart disease (CHD) versus normal subjects.
- To identify specific lipid and risk factor differences between sexes within CHD patients and controls.
Summary:
- Analysis of 72 subjects (28 CHD patients, 44 controls) revealed age-related increases in triglycerides (TG) and VLDL in normal individuals.
- In normal subjects aged 20-40, women had higher HDL and lower risk factors (RF) than men.
- CHD patients aged 40-60 showed higher total cholesterol (TC) in women than men (p<0.05).
- Male CHD patients had reduced HDL and increased RF compared to controls (p<0.05).
- Female CHD patients displayed lower HDL, higher TC, LDL, RF, and TG versus controls.
Impact:
- Findings highlight sex-specific lipid alterations in CHD.
- Identifies key lipid markers for cardiovascular risk stratification in both men and women.
- Provides data for targeted prevention and treatment strategies for coronary heart disease.
Abstract:
The lipoproteic state of 28 patients with coronary heart disease (CDH) and 44 normal subjects (total N. 72) has been analyzed. In normal subjects the results showed an increase of triglyceride (TG), VLDL with age. For subjects between 20 and 40 years of age, higher values of HDL and lower RF were observed in women than in men. In CHD patients, between 40 and 60 years, higher values of total cholesterol (TC) were observed in women than in men (p less than 0,05). The comparison between male CHD patients and normal male subjects indicated a reduction of HDL and an increase of the risk factor (RF) (p less than 0,05) in coronary patients. However, the female patients showed lower levels of HDL in combination with higher values of TC, LDL, RF, and TG when compared with the control group.