Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classical conditioning mediated by the red nucleus in the cat

N Tsukahara, Y Oda, T Notsu

    The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
    |January 1, 1981
    PubMed
    Summary

    This study models classical conditioning in the corticorubrospinal system. Findings suggest synaptic modification in this pathway underlies learned behavioral responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Single-molecule quantum dot as a Kondo simulator.

    Nature communications·2017
    Same author

    Effects of Uric Acid on the NO Production of HUVECs and its Restoration by Urate Lowering Agents.

    Drug research·2016
    Same author

    Carvedilol Suppresses Apoptosis and Ion Channel Remodelling of HL-1 Cardiac Myocytes Expressing E334K cMyBPC.

    Drug research·2015
    Same author

    Apoptosis-mediated seasonal testicular regression in the Japanese Jungle Crow (Corvus macrorhynchos).

    Theriogenology·2012
    Same author

    Krüppel-like factor 4 mediates anti-proliferative effects of progesterone with G₀/G₁ arrest in human endometrial epithelial cells.

    Journal of endocrinological investigation·2010
    Same author

    [Calcium intake and osteoporosis in many countries].

    Clinical calcium·2005

    Area of Science:

    • Neuroscience
    • Behavioral Science

    Background:

    • Classical conditioning is a fundamental learning process.
    • Understanding the neural basis of associative learning is crucial for neuroscience.

    Purpose of the Study:

    • To develop a behavioral and neuronal model for classical conditioning.
    • To investigate the neural mechanisms underlying associative learning in the corticorubrospinal system.

    Main Methods:

    • Classical conditioning paradigm using a conditioned stimulus (CS) to the cerebral peduncle and an unconditioned stimulus (US) to the forelimb in cats with specific lesions.
    • Assessing behavioral responses (elbow flexion) and comparing cerebellar nucleus interpositus function between experimental and control groups.

    Main Results:

    • A conditioned response (elbow flexion) was established after pairing CS and US.
    • The conditioned response exhibited features of associative learning, including extinction through CS alone or backward pairing.
    • The interpositorubrospinal system was ruled out as the site of plasticity.

    Conclusions:

    • The corticorubrospinal system is likely involved in mediating the conditioned response.
    • Plastic changes at corticorubral synapses are proposed as the underlying mechanism for this learned behavior.

    Related Experiment Videos