Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects of vancomycin on renal function in rats

G R Aronoff, R S Sloan, C B Dinwiddie

    Antimicrobial Agents and Chemotherapy
    |February 1, 1981
    PubMed
    Summary

    Vancomycin, an antibiotic, did not significantly impact rat kidney function across various doses. Mild kidney tissue changes were observed only at the highest vancomycin levels, suggesting minimal renal risk.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The slime loosener strikes again!

    Journal of molecular medicine (Berlin, Germany)·2000
    Same author

    Antiphospholipid antibody syndrome and appendicitis.

    The American journal of medicine·2000
    Same author

    Erythropoietin and arterial hypertension.

    Clinical nephrology·2000
    Same author

    Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families.

    Clinical genetics·2000
    Same author

    STOPPING at the CAPPP of good HOPE.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2000
    Same author

    The patient with low back pain and acute oliguric renal failure.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2000

    Area of Science:

    • Pharmacology
    • Nephrology
    • Toxicology

    Background:

    • Vancomycin is a critical antibiotic for treating serious Gram-positive bacterial infections.
    • Understanding the potential renal toxicity of vancomycin is crucial for safe clinical use.

    Purpose of the Study:

    • To evaluate the impact of varying vancomycin doses on rat renal function and kidney histology.
    • To determine the dose-dependent nephrotoxicity of vancomycin in an animal model.

    Main Methods:

    • Rats were administered daily doses of vancomycin ranging from 10 to 400 mg/kg.
    • Renal function was assessed by measuring creatinine clearance and urine protein excretion.
    • Urine osmolality and kidney tissue histology were examined.

    Main Results:

    • No significant changes in creatinine clearance or urine protein excretion were observed across tested doses.
    • Urine osmolality remained unchanged compared to control groups.
    • Mild histopathological alterations in kidney tissue were noted exclusively at the highest vancomycin dose (400 mg/kg).

    Conclusions:

    • Vancomycin administration did not lead to significant functional impairment of the kidneys in rats.
    • Nephrotoxicity, indicated by histological changes, was only apparent at very high vancomycin concentrations.
    • These findings suggest a low risk of significant renal dysfunction with therapeutic vancomycin use.

    Related Experiment Videos