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Hemoglobin A1c determinations in diabetic pregnancy

H Madsen, J Ditzel, P Hansen

    Diabetes Care
    |September 1, 1981
    PubMed
    Summary

    Hemoglobin A1c (HbA1c) correlates with average blood glucose in pregnant diabetics but is a poor predictor for individual glucose control. It serves as a valuable indicator of diabetic control quality during pregnancy.

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    Area of Science:

    • Endocrinology
    • Maternal-Fetal Medicine
    • Clinical Chemistry

    Background:

    • Diabetes in pregnancy poses risks to both mother and infant.
    • Monitoring glycemic control is crucial for managing pregnancy outcomes.
    • Hemoglobin A1c (HbA1c) offers a long-term measure of glucose control.

    Purpose of the Study:

    • To assess the relationship between HbA1c and average blood glucose levels.
    • To investigate the correlation between HbA1c and infant birth weight in diabetic pregnancies.
    • To evaluate HbA1c as a predictor of glycemic control in pregnant individuals.

    Main Methods:

    • HbA1c levels were measured in 42 insulin-dependent pregnant women in their third trimester.
    • Correlation analyses were performed between HbA1c, average blood glucose, and infant birth weight.

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  • Subgroup analyses were conducted based on pregnancy classifications and complications.

    • Main Results:

    • HbA1c showed a significant correlation with average blood glucose over the preceding 8 weeks (r=0.73).
    • No overall correlation was found between HbA1c and infant birth weight ratio.
    • In specific subgroups (White class B and C without bad signs), HbA1c correlated with birth weight ratio (r=0.59).
    • HbA1c was a poor predictor of individual average blood glucose levels, necessitating simultaneous blood glucose monitoring.
    • Increased HbA1c indicated impaired diabetic control during pregnancy.

    Conclusions:

    • HbA1c is a valuable supplementary indicator of diabetic control quality in pregnancy.
    • Simultaneous blood glucose measurements are essential for comprehensive diabetes management.
    • The study observed satisfactory perinatal outcomes with low rates of mortality and morbidity.