[Correlative studies comparing the value of transthoracic needle biopsy and open lung biopsy in disseminated lung diseases]

To compare the values of transthoracic needle biopsy and open lung biopsy on 130 patients with disseminated lung diseases transthoracic needle biopsies were carried out immediately before open lung biopsies (including the punction area). A conclusive diagnosis was obtained in 98% by open lung biopsy but only in 42% by transthoracic needle biopsy. In cases of pulmonary fibrosis and sarcoidosis needle biopsies gave a positive result in 50% whereas in other diseases like tuberculosis and silicosis in not more than one third a correct diagnosis has been achieved. The results of the direct comparisons demonstrate the superiority of open lung biopsy in diagnostics of disseminated lung alterations.