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A study on renal function in the Indian buffalo (Bubalus bubalis)

K J Varma, B S Paul, T E Powers

Journal of Veterinary Pharmacology and Therapeutics

|December 1, 1981

Summary

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This study estimated kidney function in buffalo using inulin and para-aminohippuric acid (PAH) clearance. A two-compartment model best described the data for glomerular filtration rate (GFR) and effective renal plasma flow (ERPF).

Area of Science:

Veterinary Medicine
Renal Physiology
Animal Science

Background:

Accurate assessment of kidney function is crucial in veterinary medicine.
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) are key indicators of renal health.
Limited data exists on renal function parameters in buffalo species (Bubalus bubalis).

Purpose of the Study:

To estimate GFR and ERPF in buffalo species using a single injection technique.
To evaluate the suitability of different mathematical models for pharmacokinetic analysis of renal function markers in buffalo.
To establish baseline renal function data for this species.

Main Methods:

Inulin and para-aminohippuric acid (PAH) were administered intravenously as a single bolus injection to buffalo.

Related Experiment Videos

Plasma concentrations of inulin and PAH were measured over time to generate time-concentration curves.

Total body clearances of inulin and PAH were calculated as estimates of GFR and ERPF, respectively.

Three mathematical models (including single and two-compartment models) were applied to fit the generated data.

Main Results:

The two-compartment model provided the best fit for the time-concentration data of both inulin and PAH.
The single-compartment model yielded slightly higher estimates for GFR and ERPF but demonstrated reasonable accuracy.
This suggests that simplified models can be utilized under specific practical constraints.

Conclusions:

The single injection technique is a viable method for estimating GFR and ERPF in buffalo.
The two-compartment model offers the most accurate representation of renal function in this species.
The single-compartment model presents a practical alternative for estimating renal function when extensive sampling is not feasible in buffalo research or clinical settings.