Related Experiment Video

Updated: Sep 2, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Fungal infection associated with gastroduodenal ulceration: endoscopic and pathologic appearances

M Peters, J Weiner, G Whelan

    Gastroenterology
    |February 1, 1980
    PubMed

    Insights

    Fungal infections complicated peptic ulcers in seriously ill patients, leading to fatal arterial erosion in two cases. Early fungal diagnosis through cultures may improve outcomes for susceptible individuals.

    Area of Science:

    • Medical Mycology
    • Gastroenterology
    • Pathology

    Background:

    • Peptic ulcers are a significant clinical concern, particularly in severely ill patients.
    • Fungal infections can present as opportunistic complications in compromised individuals.

    Observation:

    • Three seriously ill patients with peptic ulcers were studied.
    • Fungi were identified in ulcer biopsies and postmortem specimens.
    • Two patients experienced fatal arterial hemorrhage due to fungal invasion of ulcer walls.

    Findings:

    • Fungal presence in peptic ulcers can be associated with severe morbidity and mortality.
    • Invasive fungal infection can lead to catastrophic vascular erosion.
    • Diagnosis of fungal elements in ulcer biopsies and other samples is crucial.

    Implications:

    • Early detection of fungal elements in peptic ulcers is vital for timely intervention.
    • Diagnostic methods like fungal cultures from ulcer biopsies, throat swabs, and stool samples should be considered in susceptible patients.
    • Improved diagnostic strategies may lead to better therapeutic outcomes and reduced mortality in fungal-associated peptic ulcer disease.

    More Related Videos

    Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization10:08

    Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization

    Published on: November 5, 2019

    Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia03:05

    Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

    Published on: February 16, 2024

    Related Concept Videos

    Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

    Pathophysiology of Peptic Ulcer Disease: Injurious Factors

    Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
    In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
    Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

    Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

    Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
    Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
    Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

    Endoscopic Procedures I: Esophagogastroduodenoscopy

    An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
    During an EGD, the endoscope can be used to:
    Peptic Ulcer01:27

    Peptic Ulcer

    Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
    Gastritis II: Pathophysiology01:26

    Gastritis II: Pathophysiology

    The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
    Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

    Peptic Ulcer Disease III: Clinical Manifestations and Complications

    Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...