Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A receptor for 'self' on lymphocytes

H Kolb

    Immunology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Lymphocytes can form rosettes with red blood cells from various species, suggesting specific cell surface receptors. This rosette formation occurs across different lymphocyte types, including T-cells and B-cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer's Disease.

    The journal of prevention of Alzheimer's disease·2024
    Same author

    JCV seroconversion rate during the SARS COVID-19 pandemic.

    Multiple sclerosis and related disorders·2022
    Same author

    Reinforcing the evidence of oligoclonal bands as a prognostic factor in patients with Multiple sclerosis.

    Multiple sclerosis and related disorders·2021
    Same author

    Simultaneous measurement of all thermoelectric properties of bulk materials in the temperature range 300-600 K.

    The Review of scientific instruments·2015
    Same author

    Type I diabetes - an autoimmune disease?

    Immunology today·2014
    Same author

    New concepts in immunotherapy.

    Immunology today·2014
    Same journal

    Epidermal Dominance of Metabolically Constrained Immune Niches Underpins Immune Activation Signatures and Clinical Severity in Psoriatic Disease.

    Immunology·2026
    Same journal

    Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders.

    Immunology·2026
    Same journal

    Immune Checkpoints in Leukaemia as Gatekeepers of Immuno-Modulation.

    Immunology·2026
    Same journal

    Senescent Human Liver Endothelial Cells Mediate CD4<sup>+</sup> T Cell Recruitment via ICOSL.

    Immunology·2026
    Same journal

    The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> Double Negative T Cells in lpr Lupus Mice.

    Immunology·2026
    Same journal

    Epigenetic Gene Networks Governing Immune State Transitions Across the Lifespan.

    Immunology·2026
    See all related articles

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Lymphocytes play a crucial role in the immune system.
    • Erythrocytes (red blood cells) are involved in various cellular interactions.

    Purpose of the Study:

    • To investigate the phenomenon of lymphocyte-erythrocyte rosette formation.
    • To determine the specificity and cell-type distribution of rosette-forming cells.

    Main Methods:

    • Incubation of lymphocytes with erythrocytes from different species (syngeneic, allogeneic, xenogeneic).
    • Analysis of rosette formation using spleen cells and thymus cells from mice, rats, and rabbits.
    • Comparison of rosette formation in normal mice versus congenitally athymic (nude) mice.

    Main Results:

    • A significant population of lymphocytes formed rosettes with erythrocytes from closely related species.

    Related Experiment Videos

  • Up to 30% of mouse lymphocytes bound autologous erythrocytes.
  • Rosette formation was not observed with erythrocytes from distantly related xenogeneic species, indicating stereospecificity.
  • Both B-cells and T-cells, as well as lymphocytes from athymic mice, exhibited rosette formation.

    • Conclusions:

    • Lymphocyte-erythrocyte rosette formation is mediated by stereospecific cell surface receptors.
    • The ability to form rosettes is not restricted to specific lymphocyte subsets (B or T cells).
    • This interaction provides insights into lymphocyte surface receptor characteristics and cross-species cellular recognition.