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Experimental ocular cryptococcosis. Preliminary studies in cats and mice
Investigative Ophthalmology & Visual Science
|January 1, 1980
Summary
This study created ocular cryptococcosis in cats using Cryptococcus neoformans. The number of organisms inoculated influenced disease severity and systemic spread, offering insights into ocular fungal infections.
Area of Science:
- Veterinary Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Ocular cryptococcosis is a serious fungal infection.
- Understanding its pathogenesis is crucial for treatment.
Purpose of the Study:
- To establish an animal model for ocular cryptococcosis in cats.
- To investigate the relationship between inoculum size and disease progression.
Main Methods:
- Intracarotid injection of Cryptococcus neoformans in cats.
- Intracerebral infection in mice to study optic nerve involvement.
Main Results:
- Cats developed progressive, multifocal chorioretinitis similar to natural feline disease.
- Inoculum size correlated with ocular and systemic disease severity.
- Mice developed optic nerve meningitis.
Conclusions:
- The feline model effectively mimics naturally occurring ocular cryptococcosis.
- Inoculum size is a critical factor in disease manifestation and spread.
- This model aids in studying the pathogenesis of fungal eye infections.