Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluating patients' warfarin requirements

B R Jones, A Baran, M M Reidenberg

    Journal of the American Geriatrics Society
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Improving sensitivity and selectivity of human ACTH[1-39] quantitation using online size exclusion chromatography and antibody-free LC-HRMS.

    Bioanalysis·2025
    Same author

    Effects of cervical stabilization training in patients with headache: A single-blinded randomized controlled trial.

    European journal of pain (London, England)·2023
    Same author

    Kynurenine Pathway in Psoriasis-a Promising Link?

    Dermatology and therapy·2023
    Same author

    Reducing oxidative stress by κ-carrageenan and C60HyFn: The post-thaw quality and antioxidant status of Azari water buffalo bull semen.

    Cryobiology·2023
    Same author

    Can drug-induced aseptic meningitis account for some cases of eosinophilic meningitis/meningoencephalitis in dogs?

    New Zealand veterinary journal·2021
    Same author

    Animal medical genetics: a historical perspective on more than 50 years of research into genetic disorders of animals at Massey University.

    New Zealand veterinary journal·2021
    Same journal

    Utilization Patterns Among Heterogeneous Subgroups of Homebound Older Adults: A Latent Class Analysis.

    Journal of the American Geriatrics Society·2026
    Same journal

    Off-Label Initiation of Gabapentin and Valproic Acid Among Long-Stay Nursing Home Residents With and Without Dementia.

    Journal of the American Geriatrics Society·2026
    Same journal

    The DOAC-FRAIL Study-Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents.

    Journal of the American Geriatrics Society·2026
    Same journal

    Practice Environment and Job Outcomes Among Primary Care Nurse Practitioners Caring for Patients With Dementia.

    Journal of the American Geriatrics Society·2026
    Same journal

    Anticholinergic Medication Use in Veterans Affairs Long-Term Care Residents: Clinical Patterns and Opportunities for Deprescribing.

    Journal of the American Geriatrics Society·2026
    Same journal

    Perioperative Transfusion Trigger Score Versus Restrictive Transfusion in Older Non-Cardiac Surgery Patients: A Multicenter Randomized Controlled Trial.

    Journal of the American Geriatrics Society·2026
    See all related articles

    Warfarin anticoagulant therapy response to loading and maintenance doses moderately correlates. A weak response to warfarin loading dose predicts a higher maintenance dose need in patients.

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Medical Science

    Background:

    • Warfarin is a widely used anticoagulant.
    • Predicting patient response to warfarin is crucial for effective therapy.
    • Individual variability in warfarin response necessitates careful dosing.

    Purpose of the Study:

    • To investigate the relationship between patient response to warfarin loading dose and maintenance dose.
    • To determine if loading dose response can predict maintenance dose requirements.
    • To identify factors influencing warfarin sensitivity.

    Main Methods:

    • Seventy consecutive patients receiving warfarin were analyzed.
    • The study assessed the correlation between initial warfarin response and subsequent maintenance dosing.

    Related Experiment Videos

  • Exclusion criteria were minimal, including no complicating diseases or concurrent drug use.

    • Main Results:

    • A moderate positive correlation (r = 0.54, p < 0.01) was found between warfarin loading and maintenance dose responses.
    • A weaker response to the initial warfarin loading dose predicted a higher maintenance dose requirement.
    • Age was a weak determinant of warfarin sensitivity, with genetics and other factors being more significant.

    Conclusions:

    • Warfarin loading dose response can predict maintenance dose needs in unselected patients.
    • Initial warfarin dosing response offers valuable insights for long-term anticoagulant management.
    • Genetic factors, drug interactions, and comorbidities significantly influence warfarin efficacy more than age.